Panelists will share findings from the first two years of a five-year NSF grant titled Collaborative Research: An Interdisciplinary Approach to Understanding, Modeling, and Disrupting Drug and Counterfeit Illicit Supply Chains. Global illicit supply chains in the open and dark web are analyzed using rich corporate data focusing on counterfeit PPE and counterfeit pharmaceuticals. Research reveals a rise in counterfeits during a surge in e-commerce and the convergence of these operations with other transnational crimes. Advanced data analytics are used to map the global illicit supply chains. This effort has contributed to the seizure of over 59 million counterfeit masks worldwide and has been awarded prizes for saving lives and improving public health.